In the oven: Roast in an uncovered shallow roasting pan at 350 degrees for about 4 hours (45 minutes per pound). In the smoker: Smoke the meat at about 225-250 degrees for about 9 hours (between 1.5 and 2 hours per pound of uncooked meat.) A smoked Boston butt is ready to serve in slices when the internal temperature is about 170 degrees. A smoked Boston butt is ready for pulling into pulled pork sandwiches when the temperature of the meat is over 190 degrees
